非编码RNA在胚胎发育过程中的作用

doi:10.11843/j.issn.0366-6964.2017.01.001

Abstract

Abstract:

Embryogenesis was a complex progress which is regulated by many transcriptional regulation factors. With the development of high-throughput sequencing technology, non-coding RNAs (ncRNAs) are found to play an important role in the embryogenesis, X chromosome inactivation, gender regulation and the development of animal brain. Firstly, miRNAs regulate the expression of genes related to embryogenesis through targeting the 3′ UTR of the targeted mRNAs. Secondly, lncRNAs mediate mammal X chromosome inactivation and insect X chromosome dosage compensation through interfering transcription or modifying chromatin. Thirdly, piRNAs can maintain the DNA integrity of the germ cell in the way of silencing transposon and regulating silkworm sex differentiation. Lastly, circRNAs can act as the spongy of miRNAs and play a great role in the development of mammal animal brain. Here, we elucidate the advances of ncRNAs through the regulation during animal embryogenesis, which will provide a reference for further study on the mechanism of ncRNA during the embryogenesis.

CLC Number:

S813.1

WU Hao, ZHANG Yun-hai, LING Ying-hui. The Progress of Recent Advances in the ncRNA-Mediated Regulation during Embryogenesis[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2017, 48(1): 1-7.

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The Progress of Recent Advances in the ncRNA-Mediated Regulation during Embryogenesis

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